Monday, September 23, 2019

Treatments for Type 1 Diabetes Mellitus Research Paper

Treatments for Type 1 Diabetes Mellitus - Research Paper Example Since its earliest explanation many of years ago, diabetes has remained a chronic progressive illness (Rubino et al. 1). The illness now affects over 200 million individuals globally, and diabetes-associated death is anticipated to go up by 50% in the next decade. The occurrence of the disease, from 1994 to 2004, among elderly individuals, went up by 63% (Rubino et al. 1). Diabetes is, at the moment, ranked as the 6th leading cause of death in the United States (Rubino et al. 1). In many other nations, it ranks far higher due to their extremely poor techniques of dealing with the illness. In the United States Prospective Diabetes Study, people with diabetes were treated with insulin, diet modification, sulfonylurea and metformin in order to ease the illness (Sloan 194). Even with the innovative pharmacotherapies (drug therapies), diabetic patients still develop micro- and macro-vascular effects. Diabetes is associated with increased stroke- and cardiac-related deaths, blindness and k idney failure, as well as 69% of the non-trauma lower-limb amputations (Sloan 194). The illness as a preoperative risk element confers much better morbidity than a previous myocardial infarction in cardiac surgery. Whereas this numbers indicate to us that this disease will be a global health concern of the next generation, its actual pathophysiology is yet to be defined. Alternative treatments targeting diverse models of this disease need vigilant and responsible assessment. A tremendous body of proof now showcases that surgery for type 1 diabetes can achieve complete illness remission, an objective almost unprecedented in recent diabetes care (Perry 22; Montenero 98; Fox 1550). Data gathered over many years of surgery showcases the success and durability of diabetes management gained after the surgery. Metabolic surgery is, at the moment, emerging as a field devoted to the development of surgical processes, particularly intended to treat diabetes. However, what about non-surgical treatment? Type 1 is treated non-surgically with insulin replacement – normally through an insulin pump or insulin injection, along with dietary management, usually including vigilant monitoring of blood glucos e levels with the use of glucose meters and carbohydrate tracking (Fox 1545). This paper will center on whether one should consider surgical or non-surgical treatment for diabetes. It will discuss the many surgical and non-surgical options currently available, as well as those under study. Evidence In the early 80’s, medical surgeons identified that a lot of patients with type 1 diabetes (T1D) who had undergone pancreas transplant and islet cell transplant for treatment of the disease experienced a complete diabetes remission (Fox 1546). This remission confirmed to be durable. Since then, numerous studies have come up confirming the efficiency of pancreas transplant and islet cell transplant in treating T1D. In the meta-analysis of 30,000 diabetic patients, Cremieux (590) found diabetes resolution in 97.6 percent of patients experiencing biliopancreatic change or duodenal exchange, 84.9 percent resolution after islet cell transplant, as well as 47.9 percent diet management. I n an American diabetes study, a probable case-matched study compared diabetic patients undergoing surgery (pancreas or islet cell) with medication or non-surgical procedures (Rubino et al. 1). The data was gathered from 4,000 diabetic patients, who were tracked for over two years and others tracked for over a decade. The occurrence of diabetes at two and 10 years was overwhelmingly lower in the group that underwent surgery compared to the individuals who went for conventional treatment (Rubino et al. 1). Diabetes reduction rates as two and 10 years were 80 percent and 30 percent respectively following surgery and 20 percent and 11 percent with medical therapy respectively. A lot of people have argued that the decade remission rate is much lower than expected due to the high percentage rate of

No comments:

Post a Comment

Note: Only a member of this blog may post a comment.